Contrary Capital

Venture firm

Contrary Capital investment thesis

What a virtual cell can do rests on a key insight about the nature of cells themselves. A human cell contains an estimated several billion protein molecules, and in principle, those molecules could combine in an astronomical number of ways. But in practice, biology's internal rules, including feedback loops, regulatory dependencies, and evolutionary constraints, massively restrict which combinations actually occur. The result is that a cell's functional state, despite its underlying molecular complexity, is highly compressible. Measurements like gene expression, which captures which genes are turned on or off, and epigenomic state, which captures which genes are accessible or locked away, preserve a large share of the information needed to predict how a cell will respond to a perturbation.

Contrary Capital team (6)

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